Surgical pathology criteria use browser back button to return mucinous adenocarcinoma of the colon and rectum definition adenocarcinoma, arising in the colon or rectum, of which >50% of the lesion is composed of mucin return to colorectal adenocarcinoma nos diagnostic criteria colorectal adenocarcinoma of which >50% of the lesion is extracellular mucin pools of mucin dissect through the stroma mucin pools contain malignant epithelium strips of cells may float freely in or partially line the pools gland formation and single cells may be seen signet ring cells may be present if >50% of cells are signet ring, see signet ring adenocarcinoma if <50% of lesion is composed of mucin, designate as: adenocarcinoma with mucinous component robert v rouse md department of pathology stanford university school of medicine stanford ca 94305-5342 original posting/updates : 1/31/10, 11/12/11 supplemental studies immunohistology results for colorectal adenocarcinoma nos p63 negative ck5/6 5% cdx2 75-98% ck7 5-10% ck20 95 cdx2 has been reported to be positive in 70% of colorectal mucinous carcinomas differential diagnosis benign extravasation of mucin colorectal mucinous adenocarcinoma usually associated with a benign lesion usually has at least areas of usual adenocarcinoma usually very few epithelial cells in the pools usually areas with increased cellularity within the pools epithelium usually limited to the point of rupture usually epithelium is too widespread to be explained by rupture epithelial cells present do not show clear evidence of malignancy epithelial cells may show marked cytologic atypia or cribriform architecture usually focal and superficial usually aggressively dissecting into bowel wall frequently associated with inflammation and hemorrhage usually no inflammation or hemorrhage the presence of a mucin pool at the base of a gi epithelial neoplasm should prompt a careful examination for mucinous carcinoma clinical poor prognosis presents at higher stage than usual adenocarcinoma probably not worse than usual adenocarcinoma when corrected for stage msi-h carcinomas behave as low grade spreads preferentially to the peritoneal surface and the ovaries adenocarcinoma with mucinous component (<50%) has the same pattern of spread grading / staging grading mucinous adenocarcinoma is no longer considered definitionally high grade msi-h carcinomas are low grade mss or msi-l carcinomas are high grade staging use tnm staging see colorectal adenocarcinoma staging for problematic. when to take viagra 10mg es mejor viagra o viagra viagra cost buy viagra canada viagra coupon cheap generic viagra viagra viagra better viagra viagra or viagra which is best cost of viagra at cvs pharmacy buy generic viagra online buy viagra cheap